Fig. 2. Cinacalcet concentration versus time after a single 75mg dose. The mean reference values for C_max is 26.6 ng/mL (9.4 SD), the reference range for t_max is 1-6 hours, for bio-availability (Bio) 20-25 %, and for volume of distribution (VD) 1000-1250 L [25,33]. The reference value for the mean apparent oral clearance rate (CL/F) is 314 L/h (148 SD) [25].